Dr Barry Linnane

A graduate of University College Dublin, Dr Barry Linnane (MB BCh BAO DCH MRCPI MRCPCH MD) is a Paediatric Respiratory Consultant at the University Hospital Limerick, where he is the Director of the Paediatric Cystic Fibrosis Programme, caring for 85 children with cystic fibrosis (CF). During a two year tenure at Our Lady's Children's Hospital, Crumlin he introduced a broncho-alveolar lavage (BAL) surveillance programme for pre-school aged children with CF attending the hospital, and is in the process of setting up a similar programme in Limerick. His MD thesis, awarded in December 2009 from Melbourne University, is entitled “Early Pathophysiological Changes in the Lungs of Infants with Cystic Fibrosis”. The study involved bronchoscopy and BAL, CT thorax, and infant lung function testing to describe the early changes in the lungs of infants with CF. Dr Barry Linnane, in partnership with Dr Paul McNally, is a director of the Study of Host Immunity and Early Lung Disease in CF (SHIELD CF) project. The aim of SHIELD CF is to become a national framework for translational research into early CF lung disease.

Dr Linnane is involved in several national strategies. He was a member of the National Steering Group for the Introduction of CF Newborn Screening in Ireland and currently sits on the newly formed National Bloodspot Screening Programme Governance Group. He is a member of the Scientific Advisory Committee of the CF Registry of Ireland and is a member of the Medical and Scientific Council of the Cystic Fibrosis Association of Ireland. He is Honorary Secretary of the Irish Thoracic Society (ITS) National Council and is a member of the ITS Special Advisory Panels on Asthma, Cystic Fibrosis, and Paediatrics.

His other research interests include; preschool lung function testing, paediatric sleep medicine, asthma, and pre-school wheeze.

Publications

2022

Maguire, B., Blake, O., Boran, G., Borovickova, I., Abdelfadil, S., Murray, C., Elnazir, B., & Linnane, B. (2022). Sweat testing in the modern era: A national survey of sweat testing practice in the Republic of Ireland. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 21(3), 416–421.

Zambon, A. A., Abel, F., Linnane, B., O'Rourke, D., Phadke, R., Sewry, C. A., Sarkozy, A., Manzur, A., & Muntoni, F. (2022). Troponin-T type 1 (TNNT1)-related nemaline myopathy: unique respiratory phenotype and muscle pathology findings. Neuromuscular disorders : NMD, 32(3), 245–254.

2021

Barben, J., Castellani, C., Munck, A., Davies, J. C., de Winter-de Groot, K. M., Gartner, S., Kashirskaya, N., Linnane, B., Mayell, S. J., McColley, S., Ooi, C. Y., Proesmans, M., Ren, C. L., Salinas, D., Sands, D., Sermet-Gaudelus, I., Sommerburg, O., Southern, K. W., & European CF Society Neonatal Screening Working Group (ECFS NSWG) (2021). Updated guidance on the management of children with cystic fibrosis transmembrane conductance regulator-related metabolic syndrome/cystic fibrosis screen positive, inconclusive diagnosis (CRMS/CFSPID). Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 20(5), 810–819.

O'Sullivan, K. J., Power, V., Linnane, B., McGrath, D., Fogarty, H., Ryan, M., White, R., Noonan, C., Mulloy, E., O'Sullivan, L. W., & Dunne, C. P. (2021). An initial evaluation of the safety of a disposable oscillating positive expiratory pressure device in patients with chronic obstructive pulmonary disease: a sort-term pilot study. BMC pulmonary medicine, 21(1), 326.

Linnane, B., Walsh, A. M., Walsh, C. J., Crispie, F., O'Sullivan, O., Cotter, P. D., McDermott, M., Renwick, J., & McNally, P. (2021). The Lung Microbiome in Young Children with Cystic Fibrosis: A Prospective Cohort Study. Microorganisms, 9(3), 492.

Jenkinson, A. C., Mulligan, M., White, R., Power, N., Lynch, C., O'Connell, N., Dunne, C. P., & Linnane, B. (2021). Acinetobacter baumannii Infection in a Child with Cystic Fibrosis. Journal of paediatrics and child health, 57(7), 1148–1149.

McNally, P., Butler, D., Karpievitch, Y. V., Linnane, B., Ranganathan, S., Stick, S. M., Hall, G. L., & Schultz, A. (2021). Ivacaftor and Airway Inflammation in Preschool Children with Cystic Fibrosis. American journal of respiratory and critical care medicine, 204(5), 605–608.

O'Sullivan, K. J., Power, V., Linnane, B., McGrath, D., Mulligan, M., White, R., O'Sullivan, L. W., & Dunne, C. P. (2021).

Munck, A., Southern, K. W., Castellani, C., de Winter-de Groot, K. M., Gartner, S., Kashirskaya, N., Linnane, B., Mayell, S. J., Proesmans, M., Sands, D., Sommerburg, O., Barben, J., & European CF Society Neonatal Screening Working Group (ECFS NSWG) (2021). Defining key outcomes to evaluate performance of newborn screening programmes for cystic fibrosis. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 20(5), 820–823.

2020

Richardson, S. C., O'Riordan, A. M., Linnane, B., & Cox, D. W. (2020). Paediatric asthma deaths in Ireland: 2006-2016. Irish journal of medical science, 189(4), 1337–1342.

Rowland, M., McGee, A., Broderick, A., Drumm, B., Connolly, L., Daly, L. E., Drummond, J., Fitzpatrick, E., Linnane, B., McCormick, P. A., McNally, P., Rainford, L., Bourke, B., Cystic Fibrosis Registry of Ireland, & Cystic Fibrosis Liver Disease Research Group (2020). Repeatability of transient elastography in children. Pediatric research, 88(4), 587–592.

De Santi, C., Fernández Fernández, E., Gaul, R., Vencken, S., Glasgow, A., Oglesby, I. K., Hurley, K., Hawkins, F., Mitash, N., Mu, F., Raoof, R., Henshall, D. C., Cutrona, M. B., Simpson, J. C., Harvey, B. J., Linnane, B., McNally, P., Cryan, S. A., MacLoughlin, R., Swiatecka-Urban, A., … Greene, C. M. (2020). Precise Targeting of miRNA Sites Restores CFTR Activity in CF Bronchial Epithelial Cells. Molecular therapy : the journal of the American Society of Gene Therapy, 28(4), 1190–1199.

Useckaite, Z., Ward, M. P., Trappe, A., Reilly, R., Lennon, J., Davage, H., Matallanas, D., Cassidy, H., Dillon, E. T., Brennan, K., Doyle, S. L., Carter, S., Donnelly, S., Linnane, B., McKone, E. F., McNally, P., & Coppinger, J. A. (2020). Increased extracellular vesicles mediate inflammatory signalling in cystic fibrosis. Thorax, 75(6), 449–458.

Fitzgerald, C., Linnane, B., George, S., Ni Chroinin, M., Mullane, D., Herzig, M., Greally, P., Elnazir, B., Healy, F., Mc Nally, P., Javadpour, S., Cox, D., & Fitzpatrick, P. (2020). Neonatal screening programme for CF: Results from the Irish Comparative Outcomes Study (ICOS). Pediatric pulmonology, 55(9), 2323–2329.

Sasaki, E., Kostocenko, M., Lang, N., Clark, T., Rogers, M., Muldowney, R., Walsh, O., O'Grady, L., Edge, G., Ward, A., Linnane, B., Borovickova, I., Barton, D. E., & Lynch, S. A. (2020). National Newborn Screening for cystic fibrosis in the Republic of Ireland: genetic data from the first 6.5 years. European journal of human genetics : EJHG, 28(12), 1669–1674.

Linnane B. (2020). From micro to macro; joining the dots of early CF lung disease. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 19(6), 850–851.

2019

.Castellani, C., Linnane, B., Pranke, I., Cresta, F., Sermet-Gaudelus, I., & Peckham, D. (2019). Cystic Fibrosis Diagnosis in Newborns, Children, and Adults. Seminars in respiratory and critical care medicine, 40(6), 701–714.

Fitzpatrick, P., Fitzgerald, C., Somerville, R., & Linnane, B. (2019). Parental awareness of newborn bloodspot screening in Ireland. Irish journal of medical science, 188(3), 921–923.

O'Sullivan, K. J., Collins, L., McGrath, D., Linnane, B., O'Sullivan, L., & Dunne, C. P. (2019). Oscillating Positive Expiratory Pressure Therapy May Be Performed Poorly by Children With Cystic Fibrosis. Respiratory care, 64(4), 398–405.

O'Sullivan, D. M., Linnane, B., Hughes, J., & Murphy, A. M. (2020). Eight-month-old girl with feeding difficulties and an enlarged liver. Archives of disease in childhood. Education and practice edition, 105(6), 369–371

Kirwan, L., Fletcher, G., Harrington, M., Jeleniewska, P., Zhou, S., Casserly, B., Gallagher, C. G., Greally, P., Gunaratnam, C., Herzig, M., Linnane, B., McElvaney, N. G., McKone, E. F., McNally, P., Mullane, D., Ní Chróinín, M., O'Mahony, M., Plant, B. J., & Jackson, A. D. (2019). Longitudinal Trends in Real-World Outcomes after Initiation of Ivacaftor. A Cohort Study from the Cystic Fibrosis Registry of Ireland. Annals of the American Thoracic Society, 16(2), 209–216.

2018

Fitzpatrick, P., Fitzgerald, C., Somerville, R., & Linnane, B. (2019). Parental awareness of newborn bloodspot screening in Ireland. Irish journal of medical science, 188(3), 921–923.

O'Sullivan, D., Linnane, B., Mostyn, A., Jonathan, N., Lenihan, M., O'Connell, N. H., & Dunne, C. P. (2018). Detection of Neisseria meningitidis in a paediatric patient with septic arthritis using multiplexed diagnostic PCR targeting meningitis/encephalitis (ME). Annals of clinical microbiology and antimicrobials, 17(1), 14.

Linnane, B., & McNally, P. (2018). Six-lobe bronchoalveolar lavage in children with cystic fibrosis. The Lancet. Respiratory medicine, 6(10), e51.

McNally, P., O'Rourke, J., Fantino, E., Chacko, A., Pabary, R., Turnbull, A., Grant, T., O'Sullivan, N., Wainwright, C., Linnane, B., Davies, J. C., & Sly, P. D. (2018). Pooling of bronchoalveolar lavage in children with cystic fibrosis does not adversely affect the microbiological yield or sensitivity in detecting pulmonary inflammation. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 17(3), 391–399.

O'Sullivan, K. J., Collins, L., McGrath, D., Linnane, B., O'Sullivan, L., & Dunne, C. P. (2018). Children With Cystic Fibrosis May Be Performing Oscillating Positive Expiratory Pressure Therapy Incorrectly. Chest, 154(1), 231–232.

O'Sullivan, D. M., & Linnane, B. (2018). Recurrent haemoptysis in a child with advanced cystic fibrosis lung disease. BMJ (Clinical research ed.), 361, k1142.

2017

Fitzgerald, C., Heery, E., Conneally, N., Linnane, B., George, S. and Fitzpatrick, P. (2017) 'An evaluation of pregnant women's knowledge and attitudes about newborn bloodspot screening', Midwifery, 45, 21-27

Linnane, B., Kearse, L., O'Connell, N.H., Fenton, J., Kiernan, M.G. and Dunne, C. (2017) 'A case of failed eradication of cystic fibrosis-related sinus colonisation by pseudomonas aeruginosa', National Institute of Health Sciences, 7(4), 12.

Linnane, B., Kiernan, M.G., O'Connell, N.H., Kearse, L. and Dunne, C. (2017) 'Anti-rsv prophylaxis efficacy for infants and young children with cystic fibrosis in Ireland', National Institute of Health Sciences, 7(4), 11.

Power, R.F., Linnane, B., Martin, R., Power, N., Harnett, P., Casserly, B., O'Connell, N.H. and Dunne, C. (2017) 'The first reported case of burkholderia contaminans in patients with cystic fibrosis in Ireland- From the Sargasso sea to Irish children', National Institute of Health Sciences, 7(4), 10.

2016

Power, R. F., Linnane, B., Martin, R., Power, N., Harnett, P., Casserly, B., O'Connell, N. H. and Dunne, C. P. (2016) 'The first reported case of Burkholderia contaminans in patients with cystic fibrosis in Ireland: from the Sargasso Sea to Irish Children', BMC Pulm Med, 16(1), 57.

2015

Fitzgerald, C., Linnane, B., Heery, E., Conneally, N., George, S. and Fitzpatrick, P. (2015) 'Newborn bloodspot screening for cystic fibrosis: What do antenatal and postnatal women know about cystic fibrosis?', J Cyst Fibros, 2015/12/29.

Linnane, B., Kearse, L., O’ Connell, N.H., Kiernan, M.G., Dunne, C.P. (2015) 'Anti-RSV prophylaxis efficacy for infants and young children with cystic fibrosis in Ireland', Multidisciplinary Respiratory Medicine, 10(32).

Linnane, B., Clarke, D., Murray, P., O'Sullivan, N., Dunne, C. and McNally, P. (2015) 'The benefit of taking a control sample when performing bronchoalveolar lavage', Thorax.

Linnane, B., Kearse, L., NH, O. C., Fenton, J., Kiernan, M. G. and Dunne, C. P. (2015) 'A case of failed eradication of cystic fibrosis-related sinus colonisation by Pseudomonas aeruginosa', BMC Pulm Med, 15(1), 114.

2014

Carleton, A., Casserly, B., Power, L., Linnane, B., O’flaherty, G., Powell, J., Hartnett, P., Collins, J., Murphy, P., Kenna, D., O’connell, N. H. and Dunne, C. (2014) 'Clustered multidrug‐resistant Bordetella petrii in adult cystic fibrosis patients in Ireland: case report and review of antimicrobial therapies', JMM Case Reports, 1(1).

O’Connor, C., O'Connell, N., Power, L., Merrigan, A., Tormey, S., Coffey, J. C., Linnane, B. and Dunne, C. (2014) 'A case of Panton–Valentine leucocidin toxin‐positive Staphylococcus aureus‐mediated neonatal mastitis', JMM Case Reports, 3(2014), e004119.

Renwick, J., McNally, P., John, B., DeSantis, T., Linnane, B. and Murphy, P. (2014) 'The microbial community of the cystic fibrosis airway is disrupted in early life', PLoS One, 9(12), e109798.

Ringholz, F. C., Buchanan, P. J., Clarke, D. T., Millar, R. G., McDermott, M., Linnane, B., Harvey, B. J., McNally, P. and Urbach, V. (2014) 'Reduced 15-lipoxygenase 2 and lipoxin A4/leukotriene B4 ratio in children with cystic fibrosis', Eur Respir J, 44(2), 394-404.