Dr Leonard Browne is a Research Fellow in Biostatistics at the Graduate Entry Medical School, University of Limerick. His primary interests are in the area of modelling longitudinal data, functional data, and survival data.

Major research themes and research publications focus on the epidemiology of kidney disease; the assessment of treatment strategies for chronic kidney disease (CKD) & end-stage kidney disease (ESKD); determinants and outcomes of acute kidney injury (AKI); the clinical impact of traditional and emerging biomarkers on mortality risk which are key topics of clinical significance in the areas of nephrology and health system research.

In recent years, Dr Browne has collaborated closely with the National kidney Disease Surveillance System (NKDSS) on a number of Health Research Board funded projects in applying state-of-the-art statistical modelling to help improve our understanding of the epidemiology and clinical impact of Chronic Kidney disease, Acute Kidney Injury and disparities of care in the Irish Health System.

Professional Experience: 

  • 2017-Present: Research Fellow-Biostatistics University of Limerick
  • 2016-2017: Post-Doctoral Fellowship-Biostatistics University College Cork
  • 2014-2015:  Marie-Curie Research Fellow (IAPP) Ninewells Hospital, Dundee, UK

Research Interests: 

Dr. Browne has research interests have a strong interdisciplinary focus  with interest in the areas of areas biomedical engineering, biostatistics, epidemiology, population health, haemodynamics, vascular access, medical image segmentation, physical activity, record linkage, functional modelling, longitudinal data analysis and health technologies.

  • B.Eng. (Biomedical Engineering)
  • PhD (Biomedical Engineering)
Publications
  1. Elsayed ME, Morris AD, Li X, Browne LD, Stack AG. Propensity score matched mortality comparisons of peritoneal and in-centre haemodialysis: systematic review and meta-analysis. Nephrol Dial Transplant. 2020 Jan 25. pii: gfz278. doi: 10.1093/ndt/gfz278. [Epub ahead of print] PubMed PMID: 31981353.
  2. Mohamed H, Ali A, Browne LD, O'Connell NH, Casserly L, Stack AG, Hussein WF.  Determinants and outcomes of access-related blood-stream infections among Irish haemodialysis patients; a cohort study BMC Nephrol. 2019 Feb 26;20(1):68. doi: 10.1186/s12882-019-1253-x. PubMed PMID: 30808313; PubMed Central PMCID: PMC6390569.
  3. Powell C, Browne LD, Carson BP, Dowd KP, Perry IJ, Kearney PM, Harrington JM, Donnelly AE. Use of Compositional Data Analysis to Show Estimated Changes in Cardiometabolic Health by Reallocating Time to Light-Intensity Physical Activity in Older Adults. Sports Med. 2020 Jan;50(1):205-217. doi: 10.1007/s40279-019-01153-2. PubMed PMID: 31350674.
  4. Mohammed E, Browne LD, Kumar A U A, Adeeb F, Fraser AD, Stack A Prevalence and treatment of gout among patients with chronic kidney disease in the Irish health system: A national study. PLoS One. 2019 Jan 25;14(1):e0210487. doi: 10.1371/journal.pone.0210487. eCollection 2019. PubMed PMID: 30682034; PubMedCentral PMCID: PMC6347136.
  5. Valen-Sendstad K, Bergersen AW, Shimogonya Y, Goubergrits L, Bruening J, Pallares J, Cito S, Piskin S, Pekkan K, Geers AJ, Larrabide I, Rapaka S, Mihalef V, Fu W, Qiao A, Jain K, Roller S, Mardal KA, Kamakoti R, Spirka T, Ashton N, Revell A, Aristokleous N, Houston JG, Tsuji M, Ishida F, Menon PG, Browne LD, Broderick S, Shojima M, Koizumi S, Barbour M, Aliseda A, Morales HG, Lefèvre T, Hodis S, Al-Smadi YM, Tran JS, Marsden AL, Vaippummadhom S, Einstein GA, Brown AG, Debus K, Niizuma K, Rashad S, Sugiyama SI, Owais Khan M, Updegrove AR, Shadden SC, Cornelissen BMW, Majoie CBLM, Berg P, Saalfield S, Kono K, Steinman DA. Real-World Variability in the Prediction of Intracranial Aneurysm Wall Shear Stress: The 2015 International Aneurysm CFD Challenge. Cardiovasc Eng Technol. 2018 Dec;9(4):544-564. doi: 10.1007/s13239-018-00374-2. Epub 2018 Sep 10. PubMed PMID: 30203115; PubMed Central PMCID: PMC6290689.
  6. Stack AG, Li X, Kaballo M, Elsayed ME, Johnson H, Murray PT, Saran R, Browne LD. Temporal trends in acute kidney injury across health care settings in the Irish health system: a cohort study.  Nephrol Dial Transplant. 2018 Aug 7. doi: 10.1093/ndt/gfy226. [Epub ahead of print] PubMed PMID: 30099517.
  7. Aristokleous N, Houston JG, Browne LD, Broderick SP, Kokkalis E, Gandy SJ, Walsh MT. Morphological and hemodynamical alterations in brachial artery and cephalic vein. An image-based study for preoperative assessment for vascular access creation. Int J Numer Method Biomed Eng. 2018 Nov;34(11):e3136. doi: 10.1002/cnm.3136. Epub 2018 Sep 5. PubMed PMID: 30070048.
  8. Kumar A U A, Browne LD, Li X, Adeeb F, Perez-Ruiz F, Fraser AD, Stack AG. Temporal trends in hyperuricaemia in the Irish health system from 2006-2014: A cohort study.  PLoS One. 2018 May 31;13(5):e0198197. doi:10.1371/journal.pone.0198197. eCollection 2018. PubMed PMID: 29852506; PubMed Central PMCID: PMC5980488.
  9. Browne LD, Bashar K, Griffin P, Kavanagh EG, Walsh SR, Walsh MT. The Role of Shear Stress in Arteriovenous Fistula Maturation and Failure: A Systematic Review. PLoS One. 2015 Dec 30;10(12):e0145795. doi: 10.1371/journal.pone.0145795. eCollection 2015. Review. PubMed PMID: 26716840; PubMed Central PMCID: PMC4696682.
  10. Browne LD, Walsh MT, Griffin P. Experimental and Numerical Analysis of the Bulk Flow Parameters Within an Arteriovenous Fistula. Cardiovasc Eng Technol. 2015 Dec;6(4):450-62. doi: 10.1007/s13239-015-0246-6. Epub 2015 Sep 23. PubMed PMID: 26577478.
  11. Browne LD, Griffin P, Bashar K, Walsh SR, Kavanagh EG, Walsh MT. In vivo validation of the in silico predicted pressure drop across an arteriovenous fistula. Ann Biomed Eng. 2015 Jun;43(6):1275-86. doi: 10.1007/s10439-015-1295-6.  Epub 2015 Mar 10. PubMed PMID: 25753016.
  12. Bashar K, Healy DA, Elsheikh S, Browne LD, Walsh MT, Clarke-Moloney M, Burke  PE, Kavanagh EG, Walsh SR. One-stage vs. two-stage brachio-basilic arteriovenousfistula for dialysis access: a systematic review and a meta-analysis. PLoS One. 2015 Mar 9;10(3):e0120154. doi: 10.1371/journal.pone.0120154. eCollection 2015. Review. PubMed PMID: 25751655; PubMed Central PMCID: PMC4353636.
  13. Bashar K, Healy D, Browne LD, Kheirelseid EA, Walsh MT, Clarke-Moloney M, Burke PE, Kavanagh EG, Walsh SR. Role of far infra-red therapy in dialysis arterio-venous fistula maturation and survival: systematic review a meta-analysis. PLoS One. 2014 Aug 12;9(8):e104931. doi: 10.1371/journal.pone.0104931. eCollection 2014. Review. PubMed PMID: 25115802; PubMed Central PMCID: PMC4130633.
  14. Steinman DA, Hoi Y, Fahy P, Morris L, Walsh MT, Aristokleous N, Anayiotos AS, Papaharilaou Y, Arzani A, Shadden SC, Berg P, Janiga G, Bols J, Segers P, Bressloff NW, Cibis M, Gijsen FH, Cito S, Pallarés J, Browne LD, Costelloe JA, Lynch AG, Degroote J, Vierendeels J, Fu W, Qiao A, Hodis S, Kallmes DF, Kalsi H, Long Q, Kheyfets VO, Finol EA, Kono K, Malek AM, Lauric A, Menon PG, Pekkan K, Esmaily Moghadam M, Marsden AL, Oshima MK, atagiri K, Peiffer V, Mohamied Y, Sherwin SJ, Schaller J, Goubergrits L, Usera G, Mendina M, Valen-Sendstad K, Habets DF, Xiang J, Meng H, Yu Y, Karniadakis GE, Shaffer N, Loth F. Variability of computational fluid dynamics solutions for pressure and flow in a giant aneurysm: the ASME 2012 Summer Bioengineering Conference CFD Challenge. J Biomech Eng. 2013 Feb;135(2):021016. doi: 10.1115/1.4023382. PubMed PMID: 23445061.