Biography

Dr. Austin G. Stack, MD, MSc, FRCPI, FASN is a Consultant Nephrologist in Ireland and Professor and Chair of Medicine at the University of Limerick. Prior to his current appointment; he was Associate Professor in Medicine at the University of Texas, Houston, U.S.A. and Director of the Clinical Research Outcomes Program (2001-2004) in the Division of Renal Diseases and Hypertension.

Dr. Stack completed his residency training in Ireland and nephrology fellowship at the University of Michigan. He studied Clinical Research Design and Statistical Analysis (MSc) at the University of Michigan and was appointed to the research teams at the Kidney Epidemiology and Cost Centre (KECC), and US Renal Data System (USRDS). In 2001, he joined the Renal Division at the University of Texas as Assistant Professor of Medicine and led a successful epidemiological research and mentorship program until his move to Ireland in 2005. He was awarded his MD in Medicine (Epidemiology) in 2005.

Dr Stack has significant experience in the conduct of health outcomes and population health research in chronic kidney disease (CKD). His scientific interests include cardiovascular disease epidemiology, risk assessment, mineral metabolism, comparative effectiveness research and the identification of modifiable clinical practices in CKD. He is currently using national and regional datasets in Ireland and the US to explore several important questions. In Ireland, he is advancing the application of IT communications systems to bolster clinical and epidemiological research. As Clinical Director of the National Renal Information Project (2008), he directs the implementation of a single state-wide renal information system (eMED) for patients with kidney disease and leads a national effort to establish a CKD Surveillance System. Dr Stack is a new member of the UM-KECC team and contributes to the current CKD Surveillance project as co-investigator.

Research Interests


My research is focused on better understanding the epidemiology, risk, clinical outcomes and treatment strategies for Chronic Kidney Disease (CKD) and Acute Kidney Injury (AKI).
We are particularly interested in understanding the relationship between AKI, CKD and major clinical outcomes as well as preventive strategies using large national and international data.

Using data from the National Health and Examination Surveys (NHANES) and the US Renal Data System (USRDS), we have described the burden and clinical outcomes of several cardiovascular diseases in this vulnerable population. Our group has also advanced our understanding of treatment outcomes in dialysis and optimal dialysis strategies. Specific themes include, cardiovascular diseases and their treatment, mineral bone disease, dialysis strategies, medication prescribing, adherence to clinical guidelines, and gout and hyperuricaemia.

Our team at the Graduate Entry Medical School (GEMS) have been awarded two (3-year) HRB grants to study the epidemiology of Chronic Kidney Disease (CKD) and Acute Kidney Injury (AKI) in the Irish Health System. These studies will also provide a framework for the development of national surveillance systems that can be successfully used to track the burden, clinical outcomes and cost of kidney disease care in the health system. In support of this initiative, we also work with the HSE in the deployment of national IT system in nephrology which will be used to bolster clinical and epidemiological research in Ireland. Emerging areas of interest include Big Data in health and Connected Health in order to improve health system performance and overall patient outcomes.

Publications

Peer Reviewed Journals

2023

Ferric Carboxymaltose in Iron-Deficient Patients with Hospitalized Heart Failure and Reduced Kidney Function

Macdougall I.C.;Ponikowski P.;Stack A.G.;Wheeler D.C.;Anker S.D.;Butler J.;Filippatos G.;Göhring U.M.;Kirwan B.A.;Kumpeson V.;Metra M.;Rosano G.;Ruschitzka F.;van der Meer P.;Wächter S.;Jankowska E.A. (2023) Ferric Carboxymaltose in Iron-Deficient Patients with Hospitalized Heart Failure and Reduced Kidney Function. Clinical Journal Of The American Society Of Nephrology :1124-1134

2022

Rationale, design, demographics and baseline characteristics of the randomized, controlled, Phase 2b SAPPHIRE study of verinurad plus allopurinol in patients with chronic kidney disease and hyperuricaemia

Heerspink H.J.L.;Stack A.G.;Terkeltaub R.;Greene T.A.;Inker L.A.;Bjursell M.;Perl S.;Rikte T.;Erlandsson F.;Perkovic V. (2022) Rationale, design, demographics and baseline characteristics of the randomized, controlled, Phase 2b SAPPHIRE study of verinurad plus allopurinol in patients with chronic kidney disease and hyperuricaemia. Nephrology Dialysis Transplantation :1461-1471

2021

Effect of Intensive Urate Lowering With Combined Verinurad and Febuxostat on Albuminuria in Patients With Type 2 Diabetes: A Randomized Trial

Stack, AG;Dronamraju, N;Parkinson, J;Johansson, S;Johnsson, E;Erlandsson, F;Terkeltaub, R (2021) Effect of Intensive Urate Lowering With Combined Verinurad and Febuxostat on Albuminuria in Patients With Type 2 Diabetes: A Randomized Trial. PHILADELPHIA : W B SAUNDERS CO-ELSEVIER INC American journal of kidney diseases : the official journal of the National Kidney Foundation :481-489

2019

Poor accordance to a DASH dietary pattern is associated with higher risk of ESRD among adults with moderate chronic kidney disease and hypertension

Banerjee T.;Crews D.;Tuot D.;Pavkov M.;Burrows N.;Stack A.;Saran R.;Bragg-Gresham J.;Powe N.;Tuot D.;Hsu C.;McCulloch C.;Crews D.;Hsu R.;Grubbs V.;Bibbins-Domingo K.;Shlipak M.;Peralta C.;Rubinsky A.;Coresh J.;Rodrigue J.;Shahinian V.;Gillespie B.;Morgenstern H.;Heung M.;Herman W.;McClellan W.;Steffick D.;Tilea A.;Yin M.;Robinson I.;Zivin K.;Kurtz V.;Wyncott A.;Burrows N.;Eberhardt M.;Geiss L.;Mondesire J.;Moore B.;Patel P.;Pavkov M.;Rolka D.;Saydah S.;Shrestha S.;Waller L. (2019) Poor accordance to a DASH dietary pattern is associated with higher risk of ESRD among adults with moderate chronic kidney disease and hypertension. Kidney International

2016

Spatial and temporal clustering of anti-glomerular basement membrane disease

Canney M.;O’Hara P.;McEvoy C.;Medani S.;Connaughton D.;Abdalla A.;Doyle R.;Stack A.;O’Seaghdha C.;Clarkson M.;Griffin M.;Holian J.;Dorman A.;Niland A.;Keogan M.;Wallace E.;Conlon N.;Walsh C.;Kelly A.;Little M. (2016) Spatial and temporal clustering of anti-glomerular basement membrane disease. Clinical Journal Of The American Society Of Nephrology :1392-1399

2015

What are the Consequences of Volume Expansion in Chronic Dialysis Patients?: Pulmonary Manifestations of Volume Expansion What are the Consequences of Volume Expansion in Chronic Dialysis Patients?: Pulmonary Manifestations of Volume Expansion

Elsayed M.;Stack A. (2015) What are the Consequences of Volume Expansion in Chronic Dialysis Patients?: Pulmonary Manifestations of Volume Expansion What are the Consequences of Volume Expansion in Chronic Dialysis Patients?: Pulmonary Manifestations of Volume Expansion. Seminars in dialysis :235-239

2006

Ethnic Disparities in Cardiovascular Risk Factors and Coronary Disease Prevalence among Persons with Chronic Kidney Disease: Findings from the Third National Health and Nutrition Examination Survey (NHANES III)

Nguyen, HT; Stack, AG (2006) Ethnic Disparities in Cardiovascular Risk Factors and Coronary Disease Prevalence among Persons with Chronic Kidney Disease: Findings from the Third National Health and Nutrition Examination Survey (NHANES III). Journal Of The American Society Of Nephrology

2006

Ethnic disparities in cardiovascular risk factors and coronary disease prevalence among individuals with chronic kidney disease: findings from the Third National Health and Nutrition Examination Survey.

Nguyen HT, Stack AG (2006) Ethnic disparities in cardiovascular risk factors and coronary disease prevalence among individuals with chronic kidney disease: findings from the Third National Health and Nutrition Examination Survey.. Journal of the American Society of Nephrology : JASN :1716-1723

Books

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Conference Publications

2012

Irish Society of Nephrology

Donigiewicz, U; Abdalla, A; Weiland, A; Casserly, L; Cronin, C; Nguyen, H; Hannigan, A; Stack, A (2012) Irish Society of Nephrology.

2011

Irish Society of Nephrology

Stack, AG; Hanley, A; Mohammed, A; Tan, S; Victor, P; Mutwali, A; Saran, R (2011) Irish Society of Nephrology.

2011

Irish Society of Nephrology

Hanley, A; Mohammed, A; Tan, S; Victor, P; O'Keeffe, P; Ishag, E; Abdeljalel, W; Mutwali, A; Stack, AG (2011) Irish Society of Nephrology.

2011

Irish Society of Nephrology

Mohammed, A; Hanley, A; Tan, S; Victor, P; Mutwali, A; Saran, R; Stack, AG (2011) Irish Society of Nephrology.

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Other Publications