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Ciaran O’Malley earned his B.Sc (Hons) and M.Sc (Chemistry) from the University of Galway with his masters research focused on polymorphic control of pharmaceutical compounds by sublimation onto polycrystalline templates. For his PhD research, he was working with Dr. Andrea Erxleben and Prof. Patrick McArdle in the area of the crystal growth and design of multicomponent pharmaceuticals. His doctoral research included the design and synthesis of binary and ternary systems, the development of the sublimation method to reliably produce multicomponent crystals and morphology control over crystalline systems. His research has been published in various reputed journals with eleven articles published thus far and was the recipient of the NUIG School of Chemistry BOC postgraduate research award for 2022. Currently as a postdoctoral researcher at the Actuate lab, Ciaran is investigating the creation of orientated polycrystalline biomolecular films with Dr. Sarah Guerin.
2011–2015 BSc (Hons) Science (Chemistry) National University of Ireland, Galway / 2015– 2016 MSc Chemistry (Research) National University of Ireland, Galway / 2017- 2022 PhD Chemistry National University of Ireland Galway
(1) O’Malley, C.; Erxleben, A.; Kellehan, S.; McArdle, P. Unprecedented Morphology Control of Gas Phase Cocrystal growth using multi zone heating and tailor made additives. Chem. Commun., 2020, 42 (56), 5657-5660. https://doi.org/10.1039/D0CC01067G
(2) O’Malley, C.; Erxleben, A.; McArdle, P.; Simmie, J.M. Crystallisation of Organic Salts from the Gas Phase: When does Proton Transfer Take Place? Cryst. Growth Des., 2021, 21, (1), 23-27. https://doi.org/10.1021/acs.cgd.0c01248
(3) O’Malley, C.; Bouchet, C.; Manyara, G.; Walsh, N.; McArdle, P.; Erxleben, A.; Salts, Binary and Ternary Cocrystals of Pyrimethamine: Mechanosynthesis, Solution Crystallisation and Crystallisation from the Gas Phase. Cryst. Growth Des., 2021, 21 (1), 314-324. https://doi.org/10.1021/acs.cgd.0c01147
(4) Civati, F.; O’Malley, C.; Erxleben, A.; McArdle, P.; Factors Controlling Persistent Needle Crystal Growth: The Importance of Dominant 1D Secondary Bonding, Stacked Structures and vdW Contact. Cryst. Growth Des., 2021, 21 (6), 3449–3460. https://doi.org/10.1021/acs.cgd.1c00217
(5) O’Malley, C.; McArdle, P.; Erxleben, A.; Formation of Salts and Molecular Ionic Cocrystals of Fluoroquinolones and α,ω-Dicarboxylic Acids: Solubility Enhancement and Supramolecular Gel Formation, Cryst. Growth Des., Article ASAP, April 2022. https://doi.org/10.1021/acs.cgd.1c01509
(6) Alaa Eldin Refat, L.; O’Malley, C.; Simmie, John.; McArdle, P.; Erxleben, A. Differences in Coformer Interactions of the 2,4-Diaminopyrimidines Pyrimethamine and Trimethoprim. Cryst. Growth Des., Article ASAP, April 2022. https://doi.org/10.1021/acs.cgd.2c00035
(7) Winterlich, M.; McHugh, D.; O’Toole, E.; Skordi, K.; O’Malley, C. Sanii, R.; Tasiosopoulos, A., Erxleben, A.; Mayans, J.; Morrison, L.; McArdle, P.; Zaworotko, M.J.; Tylianakis, E.; Froudakis, G.; Papatriantafyllopoulou, C. Expanding the NUIG MOF Family: Synthesis and Characterisation of New MOFs for Selective CO2 Adsorption, Metal Ion Removal from Aqueous Systems, and Drug Delivery Applications. Dalton Trans., 2021, 20 (50), 6997-7006. https://doi.org/10.1039/D1DT00940K
(8) Fitzgerald, L.S.; O’Malley, C.; Murphy, P.V. (1R,2R,3S,4R)-1-(Acetylamino)-2,4,5-tris(acetyloxy)-1-((2S)-4-(benzyloxy)-5-oxo-2,5-dihydrofuran-2-yl)pentan-3-yl Acetate. Molbank, 2022, M1337. https://doi.org/10.3390/M1337
(9) O’Malley, C.; McArdle, P.; Erxleben, A. Crystallisation from the Gas Phase: Morphology Control, Co-Crystal and Salt Formation. Proceedings., 2021, 78 (1). Conference paper. https://doi.org/10.3390/IECP2020-08797
(10) Dimakopoulou, F., Efthymiou, C.G., O'Malley, C., Kourtellaris. A., Moushi, E., Tasiopooulos, A., Perlepes, S.P., McArdle, P., Costa-Villén, E., Mayans, J., Papatriantafyllopoulou, C. Novel Co5 and Ni4 Metal Complexes and Ferromagnets by the Combination of 2-Pyridyl Oximes with Polycarboxylic Ligands. Molecules. 2022. 27 (15), 4701. https://doi.org/10.3390/molecules27154701
(11) (7) Kamali, N., O’Malley, C., Mahon, M.F., Erxleben, A., McArdle, P. Use of Sublimation Catalysis and Polycrystalline Powder Templates for Polymorph Control of Gas Phase Crystallization. Cryst. Growth Des. 2018, 18 (6), 3510–3516. https://doi.org/10.1021/acs.cgd.8b00268