Prof. Patrick Kiely
Biography
Professor Pat Kiely is a Lecturer in the Department of Life Sciences, Principal Investigator of the Laboratory of Cellular and Molecular Biology, and member of the Materials and Surface Science Institute and Stokes Institute. Dr Kiely has a BSc. in Biomedical Science and a PhD in Biochemistry from University College Cork. Dr Kiely's work has led to a number of significant publications which were the foundation to the acquisition of several prestigious postdoctoral fellowships and international awards including European Association for Cancer Research (EACR) Young Scientist Award (2010), The Irish Cancer Society Research Fellowship (2009), The Roche Gold Medal for Postdoctoral researcher of the year (2007) The Pfizer Gold medal for Excellence in Research in 2007 and 2002, Career Development Fellowship (HRB, 2005) and Young Investigator of the Year 2006, awarded by the Biochemical Society, UK.Research Interests:
The research emphasis in my laboratory is on deciphering the localized and transient signalling events which occur in cells during migration. Cell migration is orchestrated by a series of complex signalling cascades which requires crosstalk between cell surface receptors and components of the cell cytoskeleton. Understanding the molecular mechanisms that regulate cell migration is of important intellectual and clinical interest, and we believe this work may reveal fresh approaches to target cancer as well as developmental and neurodegenerative diseases.
Research projects ongoing in the laboratory range from the most fundamental, where the development of a better understanding of the molecular mechanism(s) regulating cell migration is the goal, to the very applied, where the identification of novel therapeutic targets and the design and synthesis of novel materials and surfaces to study cell behavior is the desired endpoint. To help us achieve our goals, we are using a series of complimentary and synergistic cellular and molecular approaches and novel technologies including: 3D cell culture models, neuronal models, 2D ESI MS/MS, peptide array technology, interferometry, label free live cell monitoring, qPCR and droplet qPCR, SEM, TEM, con-focal microscopy, and electro spinning of materials. In collaboration with Dr Tara Daltons group (Stokes Institute) we are applying novel gene expression techniques and droplet technology to decipher signaling pathways in breast and colon cancer.
Research Interests
Peer Reviewed Journals
Mechanically stimulated osteocytes promote the proliferation and migration of breast cancer cells via a potential CXCL1/2 mechanism
Dwivedi, A;Kiely, PA;Hoey, DA (2021) Mechanically stimulated osteocytes promote the proliferation and migration of breast cancer cells via a potential CXCL1/2 mechanism. SAN DIEGO : ACADEMIC PRESS INC ELSEVIER SCIENCE Biochemical and biophysical research communications :14-20
Communication, collaboration and contagion: "Virtualisation" of anatomy during COVID-19.
Byrnes KG;Kiely PA;Dunne CP;McDermott KW;Coffey JC; (2021) Communication, collaboration and contagion: "Virtualisation" of anatomy during COVID-19.. Clinical Anatomy
The relationship between post-surgery infection and breast cancer recurrence.
O'Connor RÍ;Kiely PA;Dunne CP; (2020) The relationship between post-surgery infection and breast cancer recurrence.. Journal Of Hospital Infection
Inclusion of the Mesentery in Ileocolic Resection for Crohn's Disease is Associated With Reduced Surgical Recurrence
Coffey, CJ;Kiernan, MG;Sahebally, SM;Jarrar, A;Burke, JP;Kiely, PA;Shen, B;Waldron, D;Peirce, C;Moloney, M;Skelly, M;Tibbitts, P;Hidayat, H;Faul, PN;Healy, V;O'Leary, PD;Walsh, LG;Dockery, P;O'Connell, RP;Martin, ST;Shanahan, F;Fiocchi, C;Dunne, CP (2018) Inclusion of the Mesentery in Ileocolic Resection for Crohn's Disease is Associated With Reduced Surgical Recurrence. OXFORD : OXFORD UNIV PRESS Journal Of Crohns &Amp; Colitis :1139-1150
ATP synthase F-1 subunits recruited to centromeres by CENP-A are required for male meiosis
Collins, CM;Malacrida, B;Burke, C;Kiely, PA;Dunleavy, EM (2018) ATP synthase F-1 subunits recruited to centromeres by CENP-A are required for male meiosis. LONDON : NATURE PUBLISHING GROUP Nature Communications
Regulation of muscle protein synthesis in an in vitro cell model using ex vivo human serum
Carson, BP;Patel, B;Amigo-Benavent, M;Pauk, M;Gujulla, S;Murphy, S;Kiely, PA;Jakeman, PM (2018) Regulation of muscle protein synthesis in an in vitro cell model using ex vivo human serum. HOBOKEN : WILEY Experimental Physiology :783-789
P026 The role of fibrocytes in mesenteric Crohn's disease.
Kiernan MG, Sahebally SM, Kiely PA, Waldron D, Moloney M, Skelly M, Faul PN, O'Leary DP, Lowery AJ, Walsh LG, Dunne CP, Coffey JC. (2017) P026 The role of fibrocytes in mesenteric Crohn's disease.. Journal of Crohn's & colitis :S92-S93
Enhanced cell viability in hyaluronic acid coated poly(lactic-co-glycolic acid) porous scaffolds within microfluidic channels
Zamboni, F,Keays, M,Hayes, S,Albadarin, AB,Walker, GM,Kiely, PA,Collins, MN (2017) Enhanced cell viability in hyaluronic acid coated poly(lactic-co-glycolic acid) porous scaffolds within microfluidic channels. International journal of pharmaceutics :595-602
Expression of protein kinase C gamma promotes cell migration in colon cancer
Dowling, CM,Hayes, SL,Phelan, JJ,Cathcart, MC,Finn, SP,Mehigan, B,McCormick, P,Coffey, JC,O'Sullivan, J,Kiely, PA (2017) Expression of protein kinase C gamma promotes cell migration in colon cancer. Oncotarget :72096-72107
Mutant p53: a novel target for the treatment of patients with triple-negative breast cancer?
Synnott, NC,Murray, A,McGowan, PM,Kiely, M,Kiely, PA,O'Donovan, N,O'Connor, DP,Gallagher, WM,Crown, J,Duffy, MJ (2017) Mutant p53: a novel target for the treatment of patients with triple-negative breast cancer?. International Journal Of Cancer :234-246
RACK1 stabilises the activity of PP2A to regulate the transformed phenotype in mammary epithelial cells
Kiely, M,Adams, DR,Hayes, SL,O'Connor, R,Baillie, GS,Kiely, PA (2017) RACK1 stabilises the activity of PP2A to regulate the transformed phenotype in mammary epithelial cells. Cellular signalling :290-300
Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival
Dowling, CM,Phelan, J,Callender, JA,Cathcart, MC,Mehigan, B,McCormick, P,Dalton, T,Coffey, JC,Newton, AC,O'Sullivan, J,Kiely, PA (2016) Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival. Oncotarget :20919-20933
Rapid identification of antibiotic resistance using droplet microfluidics
Keays, MC,O'Brien, M,Hussain, A,Kiely, PA,Dalton, T (2016) Rapid identification of antibiotic resistance using droplet microfluidics. Bioengineered :79-87
Activation of the cAMP Pathway Induces RACK1-Dependent Binding of beta-Actin to BDNF Promoter
Neasta, J,Fiorenza, A,He, DY,Phamluong, K,Kiely, PA,Ron, D (2016) Activation of the cAMP Pathway Induces RACK1-Dependent Binding of beta-Actin to BDNF Promoter. Plos One
The importance of selecting the appropriate reference genes for quantitative real time PCR as illustrated using colon cancer cells and tissue.
Dowling CM;Dara Walsh;Coffey JC;Kiely PA; (2016) The importance of selecting the appropriate reference genes for quantitative real time PCR as illustrated using colon cancer cells and tissue.. F1000research
The presence of C/EBP alpha and its degradation are both required for TRIB2-mediated leukaemia
O'Connor, C,Lohan, F,Campos, J,Ohlsson, E,Salome, M,Forde, C,Artschwager, R,Liskamp, RM,Cahill, MR,Kiely, PA,Porse, B,Keeshan, K (2016) The presence of C/EBP alpha and its degradation are both required for TRIB2-mediated leukaemia. Oncogene :5272-5281
Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival.
Dowling CM;James J. Phelan;Callender JA;Cathcart MC;Brian J Mehigan;Paul mccormick;Dalton T;Coffey JC;Newton AC;Jacintha O'Sullivan;Kiely PA; (2016) Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival.. Oncotarget
Extracellular matrix gene expression profiling using microfluidics for colorectal carcinoma stratification
Hayes, CJ,Dowling, CM,Dwane, S,McCumiskey, ME,Tormey, SM,Merrigan, BA,Coffey, JC,Kiely, PA,Dalton, TM (2016) Extracellular matrix gene expression profiling using microfluidics for colorectal carcinoma stratification. Biomicrofluidics
Pregnancy-specific glycoprotein expression in normal gastrointestinal tract and in tumors detected with novel monoclonal antibodies
Houston, A,Williams, JM,Rovis, TL,Shanley, DK,O'Riordan, RT,Kiely, PA,Ball, M,Barry, OP,Kelly, J,Fanning, A,MacSharry, J,Mandelboim, O,Singer, BB,Jonjic, S,Moore, T (2016) Pregnancy-specific glycoprotein expression in normal gastrointestinal tract and in tumors detected with novel monoclonal antibodies. Mabs :491-500
Studying protein-protein interactions: progress, pitfalls and solutions
Hayes, S,Malacrida, B,Kiely, M,Kiely, PA (2016) Studying protein-protein interactions: progress, pitfalls and solutions. Biochemical Society Transactions :994-1004
Optimization of an in vitro bioassay to monitor growth and formation of myotubes in real time
Murphy, SM,Kiely, M,Jakeman, PM,Kiely, PA,Carson, BP (2016) Optimization of an in vitro bioassay to monitor growth and formation of myotubes in real time. Bioscience reports
High density and patternable growth of silicon, germanium and alloyed SiGe nanowires by a rapid anneal protocol
Bezuidenhout, M,Kennedy, T,Belochapkine, S,Guo, Y,Mullane, E,Kiely, PA,Ryan, KM (2015) High density and patternable growth of silicon, germanium and alloyed SiGe nanowires by a rapid anneal protocol. Journal Of Materials Chemistry C :7455-7462
Real-time cell analysis of the inhibitory effect of vitamin K<sub>2</sub> on adhesion and proliferation of breast cancer cells.
Kiely M, Hodgins SJ, Merrigan BA, Tormey S, Kiely PA, O'Connor EM (2015) Real-time cell analysis of the inhibitory effect of vitamin K<sub>2</sub> on adhesion and proliferation of breast cancer cells.. Nutrition Research
PP2A: The Wolf in Sheep's Clothing?
Kiely M, Kiely PA (2015) PP2A: The Wolf in Sheep's Clothing?. Cancers :648-669
Mapping the interaction of B cell leukaemia 3 (Bcl-3) and nuclear factor κB (NF-κB) p50 identifies a Bcl-3-mimetic anti-inflammatory peptide.
Collins PE, Grassia G, Colleran A, Kiely PA, Ialenti A, Maffia P, Carmody RJ (2015) Mapping the interaction of B cell leukaemia 3 (Bcl-3) and nuclear factor κB (NF-κB) p50 identifies a Bcl-3-mimetic anti-inflammatory peptide.. The Journal of biological chemistry
Targeting Protein Kinase C Downstream of Growth Factor and Adhesion Signalling.
Dowling CM, Kiely PA (2015) Targeting Protein Kinase C Downstream of Growth Factor and Adhesion Signalling.. Cancers :1271-1291
Real-time cell analysis of the inhibitory effect of vitamin K-2 on adhesion and proliferation of breast cancer cells
Kiely, M,Hodgins, SJ,Merrigan, BA,Tormey, S,Kiely, PA,O'Connor, EM (2015) Real-time cell analysis of the inhibitory effect of vitamin K-2 on adhesion and proliferation of breast cancer cells. Nutrition Research :736-743
Promoting Cell Proliferation Using Water Dispersible Germanium Nanowires
Bezuidenhout, M,Liu, P,Singh, S,Kiely, M,Ryan, KM,Kiely, PA (2014) Promoting Cell Proliferation Using Water Dispersible Germanium Nanowires. Plos One
Using real-time impedance-based assays to monitor the effects of fibroblast-derived media on the adhesion, proliferation, migration and invasion of colon cancer cells
Dowling, CM,Ors, CH,Kiely, PA (2014) Using real-time impedance-based assays to monitor the effects of fibroblast-derived media on the adhesion, proliferation, migration and invasion of colon cancer cells. Bioscience reports :415-127
Inhibition of transcription by B Cell Leukaemia 3 (Bcl-3) requires interaction with Nuclear Factor (NF)-κB p50.
Collins PE, Kiely PA, Carmody RJ (2014) Inhibition of transcription by B Cell Leukaemia 3 (Bcl-3) requires interaction with Nuclear Factor (NF)-κB p50.. The Journal of biological chemistry
Using real-time impedance-based assays to monitor the effects of fibroblast-derived media on the adhesion, proliferation, migration and invasion of colon cancer cells.
Dowling CM;Herranz Ors C;Kiely PA; (2014) Using real-time impedance-based assays to monitor the effects of fibroblast-derived media on the adhesion, proliferation, migration and invasion of colon cancer cells. . Bioscience reports
Promoting Cell Proliferation Using Water Dispersible Germanium Nanowires
Bezuidenhout, Michael,Liu, Pai,Singh, Shalini,Kiely, Maeve,Ryan, Kevin M.,Kiely, Patrick A. (2014) Promoting Cell Proliferation Using Water Dispersible Germanium Nanowires. : Public Library of Science PLOS ONE
RACK1 promotes neurite outgrowth by scaffolding AGAP2 to FAK
Dwane, S,Durack, E,O'Connor, R,Kiely, PA (2014) RACK1 promotes neurite outgrowth by scaffolding AGAP2 to FAK. Cellular signalling :9-18
Optimising parameters for the differentiation of SH-SY5Y cells to study cell adhesion and cell migration
Dwane S, Durack E, Kiely PA (2013) Optimising parameters for the differentiation of SH-SY5Y cells to study cell adhesion and cell migration. BMC research notes
Deubiquitination of NF-kappa B by Ubiquitin-Specific Protease-7 promotes transcription
Colleran, A,Collins, PE,O'Carroll, C,Ahmed, A,Mao, XC,McManus, B,Kiely, PA,Burstein, E,Carmody, RJ (2013) Deubiquitination of NF-kappa B by Ubiquitin-Specific Protease-7 promotes transcription. Proceedings Of The National Academy Of Sciences Of The United States Of America :618-623
Pregnancy-Specific Glycoproteins Bind Integrin alpha IIb beta 3 and Inhibit the Platelet-Fibrinogen Interaction
Shanley, DK,Kiely, PA,Golla, K,Allen, S,Martin, K,O'Riordan, RT,Ball, M,Aplin, JD,Singer, BB,Caplice, N,Moran, N,Moore, T (2013) Pregnancy-Specific Glycoproteins Bind Integrin alpha IIb beta 3 and Inhibit the Platelet-Fibrinogen Interaction. Plos One
RACK(1) to the future - a historical perspective
Ron, D,Adams, DR,Baillie, GS,Long, A,O'Connor, R,Kiely, PA (2013) RACK(1) to the future - a historical perspective. Cell Commun Signal
RACK1 promotes neurite outgrowth by scaffolding AGAP2 to FAK.
Dwane S, Durack E, O'Connor R, Kiely PA (2013) RACK1 promotes neurite outgrowth by scaffolding AGAP2 to FAK.. Cellular signalling
Dynamic complex formation between HD-GYP, GGDEF and PilZ domain proteins regulates motility in Xanthomonas campestris.
Ryan RP, McCarthy Y, Kiely PA, O'Connor R, Farah CS, Armitage JP, Dow JM (2012) Dynamic complex formation between HD-GYP, GGDEF and PilZ domain proteins regulates motility in Xanthomonas campestris.. Molecular microbiology
Direct interaction between scaffolding proteins RACK1 and 14-3-3ζ regulates brain-derived neurotrophic factor (BDNF) transcription.
Neasta J, Kiely PA, He DY, Adams DR, O'Connor R, Ron D (2012) Direct interaction between scaffolding proteins RACK1 and 14-3-3ζ regulates brain-derived neurotrophic factor (BDNF) transcription.. The Journal of biological chemistry :322-336
GSK-3β phosphorylation of the IGF-1 Receptor C terminal tail restrains kinase activity and cell growth.
Kelly GM, Buckley DA, Kiely PA, Adams DR, O'Connor R (2012) GSK-3β phosphorylation of the IGF-1 Receptor C terminal tail restrains kinase activity and cell growth.. The Journal of biological chemistry
Tools used to study how protein complexes are assembled in signaling cascades.
Dwane S, Kiely PA (2011) Tools used to study how protein complexes are assembled in signaling cascades.. Bioengineered bugs :247-259
RACK1, A multifaceted scaffolding protein: Structure and function.
Adams DR, Ron D, Kiely PA (2011) RACK1, A multifaceted scaffolding protein: Structure and function.. Cell Commun Signal
Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase.
Kiely PA, Baillie GS, Barrett R, Buckley DA, Adams DR, Houslay MD, O'Connor R (2009) Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase.. The Journal of biological chemistry :20263-20274
Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and beta1 integrin and for tumor cell proliferation and migration.
Kiely PA, Baillie GS, Lynch MJ, Houslay MD, O'Connor R (2008) Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and beta1 integrin and for tumor cell proliferation and migration.. The Journal of biological chemistry :22952-22961
Effects of RACK1 on cell migration and IGF-I signalling in cardiomyoctes are not dependent on an association with the IGF-IR.
O'Donovan HC, Kiely PA, O'Connor R (2007) Effects of RACK1 on cell migration and IGF-I signalling in cardiomyoctes are not dependent on an association with the IGF-IR.. Cellular signalling :2588-2595
Insulin-like growth factor I controls a mutually exclusive association of RACK1 with protein phosphatase 2A and beta1 integrin to promote cell migration.
Kiely PA, O'Gorman D, Luong K, Ron D, O'Connor R (2006) Insulin-like growth factor I controls a mutually exclusive association of RACK1 with protein phosphatase 2A and beta1 integrin to promote cell migration.. Molecular and cellular biology :4041-4051
Gene expression profiles in cells transformed by overexpression of the IGF-I receptor.
Loughran G, Huigsloot M, Kiely PA, Smith LM, Floyd S, Ayllon V, O'Connor R (2005) Gene expression profiles in cells transformed by overexpression of the IGF-I receptor.. Oncogene :6185-6193
Mystique is a new insulin-like growth factor-I-regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses Anchorage-independent growth.
Loughran G, Healy NC, Kiely PA, Huigsloot M, Kedersha NL, O'Connor R (2005) Mystique is a new insulin-like growth factor-I-regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses Anchorage-independent growth.. Molecular biology of the cell :1811-1822
RACK1-mediated integration of adhesion and insulin-like growth factor I (IGF-I) signaling and cell migration are defective in cells expressing an IGF-I receptor mutated at tyrosines 1250 and 1251.
Kiely PA, Leahy M, O'Gorman D, O'Connor R (2005) RACK1-mediated integration of adhesion and insulin-like growth factor I (IGF-I) signaling and cell migration are defective in cells expressing an IGF-I receptor mutated at tyrosines 1250 and 1251.. The Journal of biological chemistry :7624-7633
Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts.
Buckley DA, Cheng A, Kiely PA, Tremblay ML, O'Connor R (2002) Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts.. Molecular and cellular biology :1998-2010
RACK1 is an insulin-like growth factor 1 (IGF-1) receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death.
Kiely PA, Sant A, O'Connor R (2002) RACK1 is an insulin-like growth factor 1 (IGF-1) receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death.. The Journal of biological chemistry :22581-22589
Books
Book Chapters
The IGF-1 Receptor in Cells Survival: Signalling and Regulation.
P.A. Kiely, D.M. O'Gorman, A. Lyons, R. O'Connor (2004) The IGF-1 Receptor in Cells Survival: Signalling and Regulation.. Kluwer : Springer Cell Engineering
Edited Books
Other Journals
High density and patternable growth of silicon, germanium and alloyed SiGe nanowires by a rapid anneal protocol
Bezuidenhout, M and Kennedy, T and Belochapkine, S and Guo, Y and Mullane, E and Kiely, PA and Ryan, KM (2015) High density and patternable growth of silicon, germanium and alloyed SiGe nanowires by a rapid anneal protocol. Journal of Materials Chemistry C :7455-7462
Conference Publications
Sylvester O'Halloran Surgical Conference
Kiely M, Hodgins SJ, Tormey S, Kiely PA, O'Connor EM (2014) Sylvester O'Halloran Surgical Conference.
Conference Contributions
Published Reports
Editorials
Big Data-Led Cancer Research, Application, and Insights
Brown, JAL,Chonghaile, TN,Matchett, KB,Lynam-Lennon, N,Kiely, PA (2016) Big Data-Led Cancer Research, Application, and Insights. Cancer research :6167-6170
RACK(1) to the future - a historical perspective
Ron, D,Adams, DR,Baillie, GS,Long, A,O'Connor, R,Kiely, PA (2013) RACK(1) to the future - a historical perspective. Cell Commun Signal
Book Reviews
Other Publications
Characterisation of Chronic Lymphocytic Leukaemia (CLL) immune profiles using single cell multi-omics
Mahon, OR;King, C;Fennell, E;Hickey, SE;Kiely, PA;Clifford, R;McGourty, K (2022) Characterisation of Chronic Lymphocytic Leukaemia (CLL) immune profiles using single cell multi-omics. HOBOKEN : WILEY European Journal Of Immunology :70-70
The relationship between post-surgery infection and breast cancer recurrence
O'Connor, RI;Kiely, PA;Dunne, CP (2020) The relationship between post-surgery infection and breast cancer recurrence. LONDON : W B SAUNDERS CO LTD Journal Of Hospital Infection :522-535
Understanding the role and regulation of newly synthesized Annexin A2 in the progression of breast cancer
Mahdi, AF;Malacrida, B;Nolan, J;McGourty, K;Lowery, AJ;Kiely, PA (2019) Understanding the role and regulation of newly synthesized Annexin A2 in the progression of breast cancer. PHILADELPHIA : AMER ASSOC CANCER RESEARCH Cancer Research
Direct mechanical characterization of prostate tissue-a systematic review
Kelly, NP;Flood, HD;Hoey, DA;Kiely, PA;Giri, SK;Coffey, JC;Walsh, MT (2019) Direct mechanical characterization of prostate tissue-a systematic review. HOBOKEN : WILEY Prostate :115-125
Using hierarchical clustering of differential gene expression patterns to study the contribution of the extracellular matrix in breast cancer
Nolan, J;Mandi, AF;Lowery, AJ;Dunne, CP;Kiely, PA (2019) Using hierarchical clustering of differential gene expression patterns to study the contribution of the extracellular matrix in breast cancer. PHILADELPHIA : AMER ASSOC CANCER RESEARCH Cancer Research
Using in vitro models to identify newly synthesised proteins involved in the progression of breast cancer
Mahdi, AF;Malacrida, B;McGourty, K;Lowery, AJ;Kiely, PA (2018) Using in vitro models to identify newly synthesised proteins involved in the progression of breast cancer. PHILADELPHIA : AMER ASSOC CANCER RESEARCH Cancer Research
Elongation factor 2: A novel target for cancer progression
Malacrida, B;Dowling, CM;Flygaard, RK;Kiely, M;Coffey, JC;Jenner, LB;Kiely, PA (2018) Elongation factor 2: A novel target for cancer progression. PHILADELPHIA : AMER ASSOC CANCER RESEARCH Cancer Research
Examining how the extracellular environment alters gene expression in breast cancer
Nolan, J;Kiely, M;Dunne, CP;Lowery, AJ;Kiely, PA (2018) Examining how the extracellular environment alters gene expression in breast cancer. PHILADELPHIA : AMER ASSOC CANCER RESEARCH Cancer Research
The role of fibrocytes in mesenteric Crohn's disease
Kiernan, MG,Sahebally, SM,Kiely, PA,Waldron, D,Moloney, M,Skelly, M,Faul, PN,O'Leary, DP,Lowery, AJ,Walsh, LG,Dunne, CP,Coffey, JC (2017) The role of fibrocytes in mesenteric Crohn's disease. Journal of Crohn's & colitis :92-93
The mesentery - antagonist in Crohn's Disease?
Kiernan, MG,Sahebally, SM,Jarrar, A,Burke, JP,Hogan, J,Kiely, PA,Shen, B,Waldron, D,Moloney, M,Hogan, N,Skelly, M,Hidayat, H,Faul, PN,Mulcahy, E,Healy, V,O'Leary, DP,Lowery, A,Walsh, LG,O'Connell, PR,Martin, S,Shanahan, F,Fiocchi, C,Dunne, C,Coffey, JC (2017) The mesentery - antagonist in Crohn's Disease?. British Journal Of Surgery :22-23
The surgical and pathobiologic importance of the peritoneal reflection
Walsh, LG,Walsh, D,Kiely, PA,Dockery, P,Coffey, JC (2017) The surgical and pathobiologic importance of the peritoneal reflection. Irish journal of medical science :96-96
Faecal diversion is associated with a regression of mesenteric disease manifestations and a decrease in circulating fibrocytes in Crohn's disease
Kiernan, MG;Sahebally, SM;Tibbitts, P;Lyons, EM;Kiely, PA;O'Leary, DP;Dunne, CP;Coffey, JC (2017) Faecal diversion is associated with a regression of mesenteric disease manifestations and a decrease in circulating fibrocytes in Crohn's disease. LONDON : SPRINGER LONDON LTD Irish journal of medical science :92-93
The mesocolic hilum: an electron microscopic appraisal of anatomy
Walsh, LG,O'Brien, IS,O'Leary, DP,Kiely, PA,Dunne, C,Quandamatteo, F,Dockery, P,Coffey, JC (2016) The mesocolic hilum: an electron microscopic appraisal of anatomy. Irish journal of medical science :97-97
Big Data-Led Cancer Research, Application, and Insights
Brown, JAL,Chonghaile, TN,Matchett, KB,Lynam-Lennon, N,Kiely, PA (2016) Big Data-Led Cancer Research, Application, and Insights. Cancer research :6167-6170
Novel Role of Pregnancy Specific Glycoproteins in Platelet Integrin Binding
Golla, K,Shanley, DK,Kiely, PA,Allen, S,O'Riordan, RT,Moran, N,Moore, T (2016) Novel Role of Pregnancy Specific Glycoproteins in Platelet Integrin Binding. Irish journal of medical science :39-39
Towards a better understanding of tumour heterogeneity: a case study examining the expression pattern of protein kinase c in a triple negative metaplastic carcinoma
McCumiskey, M,Dowling, C,Murphy, M,Kelly, E,Walsh, D,Tormey, S,Merrigan, A,Lal, A,Dalton, T,Kiely, PA (2016) Towards a better understanding of tumour heterogeneity: a case study examining the expression pattern of protein kinase c in a triple negative metaplastic carcinoma. Irish journal of medical science :97-97
High density and patternable growth of silicon, germanium and alloyed SiGe nanowires by a rapid anneal protocol (vol 3, pg 7455, 2015)
Bezuidenhout, M;Kennedy, T;Belochapkine, S;Guo, Y;Mullane, E;Kiely, PA;Ryan, KM (2015) High density and patternable growth of silicon, germanium and alloyed SiGe nanowires by a rapid anneal protocol (vol 3, pg 7455, 2015). CAMBRIDGE : ROYAL SOC CHEMISTRY Journal Of Materials Chemistry C :8434-8434
Protein Kinase C In Breast Cancer Downstream Of Growth Factor And Adhesion Signalling
McCumiskey, M,Dowling, C,Dwane, S,Merrigan, A,Lal, A,Tormey, S,Murphy, M,Kelly, E,Dalton, T,Kiely, PA (2015) Protein Kinase C In Breast Cancer Downstream Of Growth Factor And Adhesion Signalling. Irish journal of medical science :397-397
PRIMA-1(MET) (APR-246): A novel targeted therapy for triple negative breast cancer?
Synnott, NC,McGowan, PM,Pierce, A,Kiely, M,O'Donovan, N,Crown, J,Kiely, PA,Duffy, MJ (2015) PRIMA-1(MET) (APR-246): A novel targeted therapy for triple negative breast cancer?. Journal Of Clinical Oncology
Identification of TTBK1 as a novel RACK1 binding partner in breast cancer
Hayes, S,Kiely, M,McCumiskey, M,Tormey, S,Dalton, T,Kiely, PA (2015) Identification of TTBK1 as a novel RACK1 binding partner in breast cancer. Irish journal of medical science :186-186
Untangling the role of protein kinase C in breast cancer downstream of growth factor and adhesion signalling
McCumiskey, M,Dowling, C,Dwane, S,Tormey, S,Dalton, T,Kiely, PA (2015) Untangling the role of protein kinase C in breast cancer downstream of growth factor and adhesion signalling. Irish journal of medical science :186-186
PDLIM2: A cytoskeleton to nuclear courier protein for the IGF-1, Wnt and TGF beta signalling pathways in Epithelial to Mesenchymal Transition
Garrido, MB,Cox, OT,O'Flanagan, C,Buckley, DA,Kiely, PA,O'Connor, R (2015) PDLIM2: A cytoskeleton to nuclear courier protein for the IGF-1, Wnt and TGF beta signalling pathways in Epithelial to Mesenchymal Transition. Cancer research
PP2A: The Wolf in Sheep's Clothing?
Kiely, M,Kiely, PA (2015) PP2A: The Wolf in Sheep's Clothing?. Cancers :648-669
Targeting Protein Kinase C Downstream of Growth Factor and Adhesion Signalling
Dowling, CM,Kiely, PA (2015) Targeting Protein Kinase C Downstream of Growth Factor and Adhesion Signalling. Cancers :1271-1291
Correlating the expression of protein kinase C isozymes with the transformed phenotype in colorectal cancer
Dowling, CM,Phelan, JJ,Cathcart, MC,Mehigan, B,McCormick, P,Dalton, T,Coffey, JC,O'Sullivan, J,Kiely, PA (2015) Correlating the expression of protein kinase C isozymes with the transformed phenotype in colorectal cancer. Cancer research
Closing a Small Gap in Our Understanding of Excitation-Contraction Coupling: JSR90/JFP90 is Junctophilin 1.
Kathleen K. English, Vincenzo Sorrentino, Anna Carla Aiello, Maeve Kiely, Patrick A. Kiely, Brian Mcdonagh, and John J. Mackrill. (2014) Closing a Small Gap in Our Understanding of Excitation-Contraction Coupling: JSR90/JFP90 is Junctophilin 1.. http://www.researchpub.org/journal/cs/cs.html Calcium Signaling
Vitamin K derivatives inhibit the growth and proliferation of triple negative breast cancer cells
Kiely, M,Hodgins, SJ,Tormey, S,Kiely, PA,O'Connor, EM (2014) Vitamin K derivatives inhibit the growth and proliferation of triple negative breast cancer cells. :27-28
Applying novel cell monitoring platforms to study the behaviour of triple negative breast cancer cells in 2-Dimensional and 3-Dimensional culture
Ogunsakin, A,Kiely, M,Tormey, S,Kiely, PA (2014) Applying novel cell monitoring platforms to study the behaviour of triple negative breast cancer cells in 2-Dimensional and 3-Dimensional culture. Irish journal of medical science :28-28
The mesenteric organ-a novel source of fibroblasts in benign and malignant colorectal disease
Sahebally, SM,Kiernan, MG,Dunne, C,Kiely, PA,Coffey, JC (2014) The mesenteric organ-a novel source of fibroblasts in benign and malignant colorectal disease. Irish journal of medical science :27-27
Correlating the expression of protein kinase C isozymes with the transformed phenotype in colorectal cancer
Dowling, CM,Hanly, J,Dalton, T,Kiely, PA (2014) Correlating the expression of protein kinase C isozymes with the transformed phenotype in colorectal cancer. Cancer Research